231 Results for "

Cercis chinensis Bunge

" in MedChemExpress (MCE) Product Catalog:
Products (231)

231 Results for "Cercis chinensis Bunge" in MCE Product Catalog:

47
Cryptotanshinone
Cryptotanshinone
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47 Publications Verification
Cat. No.: HY-N0174
CAS No.: 35825-57-1
Synonyms: Cryptotanshinon; Tanshinone c
Category:  

Quinones Labiatae Samanea saman (Jacq.) Merr. Plants Disease Research Fields Naphthalene Quinones Cancer

Target:  

STAT Autophagy

Cryptotanshinone is a natural compound extracted from the root of Salvia miltiorrhiza Bunge that shows antitumor activities. Cryptotanshinone inhibits STAT3 with an IC50 of 4.6 μM.
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37
Tanshinone IIA
Tanshinone IIA
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37 Cited Publications
Cat. No.: HY-N0135
CAS No.: 568-72-9
Synonyms: Dan Shen ketone
Category:  

Quinones Labiatae Terpenoids Samanea saman (Jacq.) Merr. Diterpenoids Plants Disease Research Fields Naphthalene Quinones Cancer

Target:  

VEGFR

Tanshinone IIA (Tan IIA) is one of the main compositions in the root of Salvia miltiorrhiza Bunge. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.
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25
Wedelolactone
Wedelolactone
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25 Cited Publications
Cat. No.: HY-N0551
CAS No.: 524-12-9
Category:  

Alysicarpus ovalifolius (Schumacher) J. Leonard Phenols Polyphenols Plants Compositae Disease Research Fields Inflammation/Immunology

Target:  

Caspase Lipoxygenase Apoptosis

Wedelolactone suppresses LPS-induced caspase-11 expression by directly inhibits the IKK Complex. Wedelolactone also inhibits 5-lipoxygenase (5-Lox) with an IC50 of 2.5 μM. Wedelolactone induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt. Wedelolactone can extract from Eclipta alba, and it can be used for the research of cancer .
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14
Dihydrotanshinone I
Dihydrotanshinone I
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14 Cited Publications
Cat. No.: HY-N0360
CAS No.: 87205-99-0
Category:  

Cardiovascular Disease Quinones Labiatae Samanea saman (Jacq.) Merr. Plants Phenanthrenequinones Disease Research Fields

Target:  

SARS-CoV

Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge which has been widely used for treating cardiovascular diseases. Dihydrotanshinone I exhibits entry-blocking effect for MERS-CoV.
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12
Schisandrin B
Schisandrin B
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12 Cited Publications
Cat. No.: HY-N0089
CAS No.: 61281-37-6
Synonyms: γ-Schisandrin; Wuweizisu B
Category:  

Neurological Disease Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer

Target:  

Autophagy Reactive Oxygen Species (ROS)

Schisandrin B (γ-Schisandrin) is a biphenylcyclooctadiene derivative isolated from Schisandra chinensis and has been shown to have antioxidant effects on the liver and heart of rodents.
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6
Periplocin
Periplocin
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6 Cited Publications
Cat. No.: HY-N1381
CAS No.: 13137-64-9
Category:  

Asclepiadaceae Plants Periploca sepium Bunge Disease Research Fields Inflammation/Immunology Steroids

Target:  

Apoptosis

Periplocin is a cardiotonic steroid isolated from root-bark Periploca sepium Bunge. Periplocin promotes tumor cell apoptosis and inhibits tumor growth. Periplocin has the potential to facilitate wound healing through the activation of Src/ERK and PI3K/Akt pathways mediated by Na/K-ATPase .
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5
Schisandrin C
Schisandrin C
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5 Cited Publications
Cat. No.: HY-N0690
CAS No.: 61301-33-5
Synonyms: Schizandrin-C; Wuweizisu-C
Category:  

Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer

Target:  

Apoptosis

Schisandrin C (Schizandrin-C) is a phytochemical lignan isolated from Schizandra chinensis . Schisandrin C has diverse biological activities, including anticancer, anti-inflammatory and antioxidant effects. Schisandrin C can be used for cancer, alzheimer’s disease, and liver diseases research . Schisandrin C induces cell apoptosis .
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5
Coptisine Sulfate
Coptisine Sulfate
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5 Cited Publications
Cat. No.: HY-N0430A
CAS No.: 1198398-71-8
Category:  

Alkaloids Chelidonium majus Metabolic Disease Quinoline Alkaloids Plants Disease Research Fields Papaveraceae

Target:  

Indoleamine 2,3-Dioxygenase (IDO) NF-κB p38 MAPK PI3K Akt Apoptosis Reactive Oxygen Species (ROS) Mitochondrial Metabolism DNA/RNA Synthesis ROCK LDLR

Coptisine Sulfate is an orally active and brain-penetrant alkaloid found in Coptis chinensis. Coptisine Sulfate is a reversible, uncompetitive IDO inhibitor with a Ki of 5.8 μM and an IC50 of 6.3 μM. Coptisine Sulfate suppresses neuroinflammation, reduces Aβ plaque burden and shows neuroprotective activity. Coptisine Sulfate shows anti-inflammation activity by blocking NF-κB, MAPK, and PI3K/Akt activation. Coptisine Sulfate inhibits cancer cells proliferation, induces DNA damage, G2/M phase cell cycle arrest, apoptosis, ROS production and mitochondrial dysfunction. Coptisine Sulfate inhibits Rho/ROCK pathway activation, reduces arrhythmia, limits cardiac injury marker release, reduces infarct size, and preserves cardiac function in rat myocardial ischemia/reperfusion models. Coptisine Sulfate downregulates HMGCR and upregulates LDLR and CYP7A1 to modulate cholesterol metabolism, reduces abnormal serum lipid levels, and promotes fecal bile acid excretion. Coptisine Sulfate be used for the research of cancer, hypercholesterolemia, Alzheimer’s disease, inflammatory disorders and cardiovascular disease .
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4
Schisandrin
Schisandrin
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4 Cited Publications
Cat. No.: HY-N0691
CAS No.: 7432-28-2
Synonyms: Schizandrin; Schizandrol; Schizandrol-A
Category:  

Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer

Target:  

Autophagy

Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats .
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4
Sarsasapogenin
Sarsasapogenin
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4 Cited Publications
Cat. No.: HY-N0073
CAS No.: 126-19-2
Synonyms: Parigenin; Sarsagenin
Category:  

Liliaceae Metabolic Disease Anemarrhena asphodeloides Bunge Plants Endogenous metabolite Disease Research Fields Inflammation/Immunology Steroids

Target:  

Endogenous Metabolite NF-κB

Sarsasapogenin is a sapogenin from the Chinese medical herb Anemarrhena asphodeloides Bunge, with antidiabetic, anti-oxidative, anticancer and anti-inflamatory activities.
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4
Danthron
Danthron
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4 Cited Publications
Cat. No.: HY-B0923
CAS No.: 117-10-2
Synonyms: Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone
Category:  

Quinones Labiatae Anthraquinones Samanea saman (Jacq.) Merr. Phenols Polyphenols Plants Disease Research Fields Cancer

Target:  

AMPK Autophagy Bacterial Virus Protease

Danthron is a natural product extracted from the traditional Chinese medicine Salvia miltiorrhiza Bunge. Danthron functions in regulating glucose and lipid metabolism by activating AMPK.
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4
Irisflorentin
Irisflorentin
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4 Cited Publications
Cat. No.: HY-N0268
CAS No.: 41743-73-1
Category:  

Iridaceae Flavonoids Plants Belamcanda chinensis (Linn.) Redouté Disease Research Fields Inflammation/Immunology Isoflavones

Target:  

NO Synthase

Irisflorentin, a naturally occurring isoflavone, is an abundant active constituent in Belamcanda chinensis. Irisflorentin markedly reduces the transcriptional and translational levels of inducible nitric oxide synthase (iNOS) as well as the production of NO. Anti-inflammatory activity .
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4
Epiberberine chloride
Epiberberine chloride
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4 Cited Publications
Cat. No.: HY-N0226A
CAS No.: 889665-86-5
Category:  

Alkaloids Neurological Disease Ranunculaceae Coptis chinensis Franch. Metabolic Disease Plants Disease Research Fields Isoquinoline Alkaloids

Target:  

Cholinesterase (ChE) Beta-secretase Reactive Oxygen Species (ROS)

Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO - scavenging effect (IC50, 16.83 μM), and may protect against Alzheimer disease . Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways . Epiberberine has the potential effect in the research of diabetic disease .
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3
Leucocyanidin
Leucocyanidin
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3 Cited Publications
Cat. No.: HY-119580
CAS No.: 480-17-1
Purity:  98.03%
Category:  

Litchi Chinensis Sonn. Plants Flavonoids Microorganisms Flavanols Sapindaceae Phenols Polyphenols Disease Research Fields Inflammation/Immunology

Target:  

Others

Leucocyanidin is an active anti-ulcerogenic ingredient was extracted from Litchi Chinensis. Leucocyanidin demonstrates a significant protective effect against Aspirin-induced erosions in rat models .
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3
Atractylodin
Atractylodin
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3 Cited Publications
Cat. No.: HY-N0238
CAS No.: 55290-63-6
Synonyms: Atractydin
Category:  

Infection Natural Products Plants Compositae Disease Research Fields Erythrina sigmoidea Hua

Target:  

Insecticide

Atractylodin (Atractydin) is an orally active active ingredient obtained from the rhizome of Atractylodes lancea and A. chinensis. Atractylodin is a natural insecticide. Atractylodin has anti-inflammatory activity .
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3
Jatrorrhizine chloride
Jatrorrhizine chloride
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3 Cited Publications
Cat. No.: HY-N0740
CAS No.: 6681-15-8
Category:  

Alkaloids Monophenols Ranunculaceae Coptis chinensis Franch. Phenols Plants Isoquinoline Alkaloids

Target:  

Cholinesterase (ChE) 5-HT Receptor Bacterial

Jatrorrhizine chloride is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine chloride is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine chloride reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .
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3
Jatrorrhizine hydroxide
Jatrorrhizine hydroxide
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3 Cited Publications
Cat. No.: HY-N0749A
CAS No.: 483-43-2
Category:  

Alkaloids Monophenols Ranunculaceae Coptis chinensis Franch. Phenols Plants Isoquinoline Alkaloids

Target:  

Cholinesterase (ChE) 5-HT Receptor Bacterial

Jatrorrhizine hydroxide is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities . Jatrorrhizine hydroxide is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE . Jatrorrhizine hydroxide reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters .
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3
Gomisin J
Gomisin J
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3 Cited Publications
Cat. No.: HY-N0385
CAS No.: 66280-25-9
Category:  

Cardiovascular Disease Monophenols Lignans Phenols Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill.

Target:  

NO Synthase AMPK CaMK NF-κB Keap1-Nrf2

Gomisin J is a Schisandra chinensis-derived lignan that can inhibit multiple targets such as eNOS, AMPK (LKB1, CaMKIIβ), fetuin-A, NF-κB, Nrf2/HO-1, and can pass through the blood-brain barrier. Gomisin J increases NO bioavailability by activating eNOS, regulates lipid metabolism by activating the AMPK pathway, inhibits fetuin-A and NF-κB to exert anti-inflammatory effects, and activates Nrf2/HO-1 to enhance antioxidant capacity. Gomisin J has the activities of anti-hypertension, regulating liver lipid metabolism, and reducing cerebral ischemia-reperfusion injury, and can be used for research on hypertension, non-alcoholic fatty liver disease, cerebral ischemia-reperfusion injury, etc .
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2
Schisandrol B
Schisandrol B
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2 Cited Publications
Cat. No.: HY-N0692
CAS No.: 58546-54-6
Synonyms: Gomisin-A; TJN-101; Wuweizi alcohol-B
Category:  

Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer

Target:  

Reactive Oxygen Species (ROS) Cytochrome P450 Autophagy

Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .
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2
Bifendate
Bifendate
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2 Cited Publications
Cat. No.: HY-W018791
CAS No.: 73536-69-3
Synonyms: DDB
Target:  

HBV Autophagy Cytochrome P450 Atg8/LC3 p62 P-glycoprotein

Research Areas:  

Infection Cardiovascular Disease Cancer

Bifendate (DDB), extracted from Schisandrae chinensis, is an orally active anti-HBV agent against chronic hepatitis B. Bifendate inhibits ATG5-dependent autophagy and attenuates oleic acid-induced lipid accumulation with anti-oxidant properties in vitro. Bifendate can decrease alanine transaminase (ALT) level in mice. Bifendate attenuates hepatic steatosis in cholesterol/bile salt- and high-fat diet-induced hypercholesterolemia in mice. Bifendate potently increases the activity of cytochrome proteins (CYPs) and reverse P-gp-mediated multi-drug resistance (MDR) .
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